Project Summary

This project seeks to:

Integrate social, Psychological, and biological measures with clinical data for Publicly funded youth with depression
Develop tools that enable timely and personalized identification, prevention, and treatment of clinical depression in publicly funded youth

Background

Publicly funded youth are youth that receive public insurance, which could include youth from low-income families, justice-involved individuals, or youth in foster care. These populations are at a disproportionately higher risk for developing clinical depression. Rates of depression rise sharply during adolescence and peak during this crucial and key developmental period, increasing the risk for associated issues and concerns, including cardiovascular disease, substance use, school and family problems, and suicide.

Precision medicine approaches that consider the whole person are critical for individualized risk prediction, prevention, and treatment of depression. These approaches include identifying youth who are most at risk for developing clinical depression based on large sets of biological and clinical data, as well as using these data to determine the most effective clinical treatments and reduce health disparities for publicly funded youth with clinical depression.

The team has partnered with community-based organizations Edgewood Center for Children and Families, Teens4Teens, as well as private sector collaborator Neumarker to bring together clinicians, neuroscientists, and community stakeholders to develop a suite of precision medicine tools designed to prevent and treat clinical depression in publicly funded youth through timely, individualized interventions.

Project Goals

This graphic describes the project goals.

This project aims to improve health outcomes in publicly funded youth and reduce health disparities by applying a precision medicine approach in:
  1. Risk prediction - identify youth who are at the highest risk for developing clinical depression
  2. Prevention - identify youth who will respond to an innovative, neuroscience-based, fully remotely-delivered mindfulness intervention designed to treat and prevent adolescent depression
  3. Treatment - identify the best clinical treatment option for youth diagnosed with depression

Method:
Reduce disparities in depression care for publicly funded youth by enablish precise risk prediction, prevention, and personalized treatment.

This graphic describes the project goals.

To sustain these efforts, the UCSF team will build a precision medicine platform using an innovative UCSF-developed “BRIDGE” dashboard to help clinicians with the identification, treatment, and prevention of depression. In performing this project, the UCSF team will help co-create with the UCSF community partner, Edgewood, a brand-new Community Advisory Board (CAB) whom they will then continue to engage with to provide feedback on various aspects of the CIAPM project.

Community Partnerships:
UCSF’s project aims to examine person-centered factors for depression risk, identification, and treatment outcomes in publicly funded youth. The UCSF team partners with Edgewood Center for Children and Families and Teens4TeensHelp, non-profit mental health organizations serving youth and supporting outreach and engagement of community stakeholders in participating in the research study and providing feedback for key study materials.
Edgewood Center for Children and Families is a San Francisco-based center that focuses on mental health. The UCSF team is partnering with Edgewood and their team of clinicians to develop and implement a sustainable Community Advisory Board (CAB) and provide community feedback to the project, particularly the precision medicine platform, for clinicians to support publicly-funded youth. Edgewood also will help with the recruitment of depressed adolescents as part of this CIAPM project for the innovative, neuroscience-based, fully remotely-delivered mindfulness intervention designed to treat and prevent adolescent depression.
Teens4TeensHelp is based in Southern California and also has a strong presence in the San Francisco area and a strong online connection to many clinical sites that serve publicly-funded youth. Teens4TeensHelp is assisting the UCSF team with outreach and recruitment of adolescents to the research study through their wide reach as an online community for teens seeking help.

Private Sector Collaborations:
NeuMarker provides cutting-edge analytic precision medicine software tools that can match a person with depression to the optimal treatment.

Potential for Impact for Californians:
Clinicians and patients will benefit from the creation of precision medicine tools to help identify risk, prevent, and treat clinical depression in publicly-funded youth via timely and individualized interventions.

Definitions

Youth supported by government programs, services, and other resources (e.g., public health insurance, delinquency prevention programs or initiatives targeting at-risk or low-income youth). These youth are disproportionately at higher risk for developing clinical depression.

A program that trains skills to promote intentional and nonjudgmental awareness of the present moment.

Team Leaders

Tony T. Yang, M.D., Ph.D.

Professor, Department of Psychiatry and Behavioral Sciences, School of Medicine, Division of Child and Adolescent Psychiatry. UCSF Weill Institute for Neurosciences. UCSF Benioff Children’s Hospital

Dr. Yang is a psychiatrist conducting extensive clinical and translational research in adolescent depression and caring for patients suffering from depression. He is currently a Professor at UCSF, where he leads the BrainChange Lab. Dr. Yang studies depression in adolescents using both structural and functional MRI, which measures brain activity. He has received funding support for his research from the Brain & Behavior Research Foundation, Klingenstein Third Generation Foundation and the National Institute of Mental Health. Dr. Yang earned his Ph.D. in molecular pathology at the University of California, San Diego, before earning his M.D. from the UC San Diego School of Medicine. He completed a residency in general psychiatry and a fellowship in child and adolescent psychiatry at Stanford University School of Medicine.

Riley Bove, M.D.

Associate Professor, Neurology
Rosenberg Ach Family Endowed Professor in Neuroimmunology
UCSF Weill Institute for Neurosciences

Dr. Riley Bove is a practicing neurologist and clinician scientist in the UCSF Weill Institute for Neurosciences. She is a national and international leader in sex and gender aspects of Neurology, publishing, collaborating, and lecturing widely on this topic. In the technology space, Dr. Bove has conducted innovative work designing, validating, and implementing digital tools to improve care access, holistic measures of patient function, and as digital therapeutics. She is co-PI of the BRIDGE precision medicine dashboard that supports delivery of point-of-care personalized care. Dr. Bove received her MD and MSc from Harvard Medical School. She completed a neurology residency in the Massachusetts General/Brigham Hospitals program, followed by a clinical research fellowship at the Partners MS Center.

Susanna Fryer, Ph.D.

Associate Professor, UCSF Weill Institute for Neurosciences

Dr. Fryer is a licensed clinical psychologist and Associate Professor at the UCSF Weill Institute for Neurosciences. She conducts research in motivation and reward processing and the neurobiology of depression. She has expertise in EEF and fMRI in her research. Dr. Fryer obtained a Ph.D. in the SDSU/UCSD Joint Doctoral Program in Clinical Psychology and completed a clinical psychology internship at the San Francisco Veterans Affairs (VA) Medical Center.

Sharat Israni, Ph.D.

Chief Technology Officer; Assoc. Adjunct Professor
UCSF Bakar Computational Health Sciences Institute

Dr. Israni is the Chief Technology Officer of the Bakar Computational Health Sciences Institute (BCHSI) at UCSF. He also has adjunct and affiliate faculty positions at UCSF and UC Berkeley. Previously, he was the Executive Director of Data Science at Stanford Medicine. Dr. Israni also has expertise in various Silicon Valley technology companies. He earned a PhD in Industrial Engineering (Computer Science minor) and an MSIE (Systems) from the University of Wisconsin, Madison; and a B.Tech. in Mechanical Engineering from the Indian Institute of Technology - Kanpur.

Yi Li, M.D.

Associate Professor
Director, UCSF Neuroradiology Fellowship Program

Dr. Li is an Associate Professor at UCSF and a Director of the Neuroradiology Fellowship Program. She obtained her MD from Harvard Medical School in Boston, MA, followed by a one-year internship at the Beth Israel Deaconess Medical Center in Boston. She then completed a four-year Diagnostic Radiology residency at UCSF. Dr. Li served as chief fellow in Neuroradiology, completing her neuroradiology fellowship in 2017 and clinical instructorship in 2018.

Kathy Long

Program Director, Teens4TeensHelp

Ms. Long is a co-founder of Teens4TeensHelp, a mother with lived family experience, and a passionate health advocate. She brings passion, experience, and a medical point of view to Teens4TeensHelp. She has also co-authored the book A Parent's Guide to Anorexia, offering parents insight into what to expect as they navigate the system of eating disorder treatment for their children.

Thomas Neylan, M.D.

Professor, Psychiatry
UCSF Weill Institute for Neurosciences
Director, Stress and Health Research Program, San Francisco Veterans Affairs Medical Center

Dr. Neylan is a Professor, In Residence, in the Departments of Psychiatry and Neurology at the University of California, San Francisco. He is the Director of the Posttraumatic Stress Disorders (PTSD) Clinic and the Stress and Health Research Program at the San Francisco Veterans Affairs Medical Center. His research has focused on the role of sleep in emotion regulation, cognitive function, and metabolic health, in patients with PTSD and in aging populations with neurodegenerative disorders. Dr. Neylan obtained his M.D. from the Rush Medical College at the Rush University Medical Center and completed psychiatry residencies at the University of Pittsburgh Medical Center and University of Pennsylvania.

Robin Randall, M.D., M.P.H

Chief Medical Officer, Edgewood Center for Children and Families

Dr. Randall leads the medical program at Edgewood Center and originally joined in 1999 as an Associate Medical Director serving youth and families. He is board-certified in general psychiatry and child and adolescent psychiatry by the American Board of Psychiatry and Neurology. Dr. Randall received his M.D. and M.P.H. degrees from Tulane University School of Medicine and Tulane School of Public Health. He completed his adult and child and adolescent psychiatry training at the University of California, San Francisco (UCSF).

Marina Tolou-Shams, Ph.D.

Kilroy Realty Endowed Professor In Psychiatry
UCSF Weill Institute for Neurosciences

Dr. Tolou-Shams is the Kilroy Realty Professor of Psychiatry and Vice Chair of Community Engagement, Outreach and Advocacy in the Department of Psychiatry and Behavioral Sciences (DPBS) at UCSF. She is also Deputy Vice Chair for Research in the DPBS at Zuckerberg San Francisco General Hospital (ZSFG). Dr. Tolou-Shams received her Ph.D. in Clinical Psychology in 2004 from the University of Illinois at Chicago and is trained as a pediatric and forensic psychologist who has many years of clinical experience with assessing and treating underserved adolescents and their families. Her 20 years of research experience has broadly focused on developing and testing integrated mental health, substance use, sexual and reproductive health prevention and treatment interventions (at individual, family and systems-levels) for youth and families in contact with the legal and/or child welfare systems.

Partners, Collaborators, and Supporters/Research Teams

  • UCSF
    • Xueyuan (Alice) Li
    • Pierre Nedelec
    • Po-Hung Wu, Ph.D.
    • Gundolf Schenk, Ph.D.
    • Tracy Luks, Ph.D.
    • Nicolette Miller
    • Kyra Henderson
    • Narender Sara
    • Riley Bove, M.D.
    • Alison Czopp
    • Angela Jakara
    • Paul Maisano
  • Edgewood Center
    • Jonathan Weinstock
    • Sandra Ramos
  • Teens4TeensHelp
    • Miranda Kramer