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California Initiative to Advance Precision Medicine Demonstration Projects

CIAPM's portfolio of demonstration projects comprises broad collaborative efforts across institutions and sectors. The activities range from discovery to clinical implementation, aiming to enable more precise, individually targeted prevention, diagnosis, and treatment of disease, and to illustrate that precision medicine is making a difference now.

Upcoming Projects

CIAPM anticipates releasing a Request for Applications (RFA) later this year, which will provide additional details on how this upcoming funding will support psychedelic research focused on veterans. Please visit the CIAPM News Page and subscribe to our newsletter for updates on the RFA announcement, application deadlines, and other important information.


Current Programs

Representative Research Partnerships Program
The California Initiative to Advance Precision Medicine (CIAPM) at the California Health and Human Services Agency announced the launch of the Representative Research Partnerships Program, awarding $6.2 million to support a cohort of four research.
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Next-Gen Representative Research Program
The California Initiative to Advance Precision Medicine (CIAPM) at the California Health and Human Services Agency announced the launch of the Next-Gen Representative Research Program, awarding $1.8 million to support a cohort of a dozen California PhD or MD-PhD student researchers.
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Depression Research Program
The California Health and Human Services Agency is pleased to announce three awardees for the California Initiative to Advance Precision Medicine request for proposals, "A Precision Medicine Approach to Improve the Prevention, Diagnosis, and Treatment of Depression."
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Adverse Childhood Experiences Research Program
CIAPM has awarded over $20 million to seven projects to address the health impacts of Adverse Childhood Experiences through a collaborative precision medicine approach.
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Completed Projects

Improving Breast Cancer in Latinas: A Multi-Tiered Approach
This project aims to better understand the role of genetics in Latinas who develop breast cancer, and to increase community awareness of hereditary cancer risk and genetic testing.
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Integrated Machine-Learning Platform to Inform Precision Therapy in Breast Cancer Patients
This project applies precision medicine genomic profiling to find new treatments and to better match certain kinds of breast tumors to cancer existing therapies.
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Reducing Cancer Disparities Through Innovative Community-Academic Partnerships
The objective of this project is to develop, implement, and evaluate a Community Health Worker approach to cancer care that increases access to precision medicine at every stage of treatment.
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Artificial Intelligence for Imaging of Brain Emergencies
This project successfully used artificial intelligence to automate brain scan evaluation.
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Early Prediction of Major Adverse Cardiovascular Events Using Remote Monitoring
This project monitored several types of patient data, including information from wearable health devices, to better predict who may be about to have a heart attack or stroke.
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Early Prostate Cancer: Predicting Treatment Response
This project focused on improving predictions about what treatment would work best for patients with early stage prostate cancer.
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Full Genome Analysis to Guide Precision Medicine
This project created a method that more thoroughly reads the entire human genome than all other available techniques.
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Precision Medicine for Multiple Sclerosis: Making it Work
This project developed an interactive digital tool to guide treatment decisions for multiple sclerosis patients that aligned with their experience, preferences, and priorities.
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Personal Mobile and Contextual Precision Health
This project developed a mobile health application to collect patient-reported data about blood pressure, mood, movement, and medication adherence.
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Precision Diagnosis of Acute Infectious Diseases
This project prepared a new method of infectious disease testing for use in clinical laboratories.
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California Kids Cancer Comparison
This project improved pediatric cancer care with novel, RNA-based treatment approaches; and by using large data sets to compare tumors between patients.
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Evaluations Report
A thorough, scientific review of CIAPM's first eight projects from a panel of experts.
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RFP Documents

Adverse Childhood Experiences (December 2019)
Full RFP
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Adverse Childhood Experiences (December 2019)
Proposal submission guidelines
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Cancer Disparities (July 2018)
Full RFP
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Cancer Disparities (July 2018)
RFP review process
download pdf
Depression RFP
Full RFP
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Depression FAQs
Full RFP
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CIAPM Depression RFP Full Proposal Instructions
Full RFP
download pdf